Howard S. Lotsof, 66, discoverer of the anti-addictive effect of ibogaine,
died of liver cancer on Sunday January 31, 2010 in Staten Island.
Mr. Lotsof was the first individual to observe the effect of
ibogaine, a naturally occurring plant alkaloid with a history of use as a
ritual hallucinogen in Africa, in detoxification from heroin. He
subsequently originated patents for the use of ibogaine in treating
addictions, including opioids, cocaine and amphetamine, alcohol, and
nicotine.
Mr. Lotsof¹s work initiated substantial research into ibogaine
and related compounds in the mainstream scientific community. He provided
pilot data to the National Institute on Drug Abuse that became the basis for
a program of research on ibogaine that generated scores of peer-reviewed
publications and led to the approval by the US Food and Drug Administration
of a Phase 1 clinical trial. Beginning with research funding provided by Mr.
Lotsof 25 years ago, Stanley D. Glick, M.D., Ph.D., Professor and Director
of the Center for Neuropharmacology and Neuroscience Albany Medical College,
has produced a body of work on ibogaine and related compounds that presently
includes over 60 peer-reviewed publications and has been supported for more
than two decades by the National Institutes of Health. Mr. Lotsof himself
authored or coauthored scientific papers on ibogaine in respected academic
publishing venues such as the Journal of Ethnopharmacology and the American
Journal on Addictions. These accomplishments are all the more extraordinary
in view of the fact that Mr. Lotsof, a graduate of NYU who majored in film
was without a doctoral level degree.
The FDA-approved clinical study was never completed due to
contractual disputes, which was Mr. Lotsof¹s deepest professional
disappointment. Nonetheless, an expanding global context of ibogaine use for
the treatment of addiction continues to exist in medical and non-medical
settings across the world, and ibogaine continues to be studied as a
paradigm for fundamental research and the development of new treatment for
addiction.
Mr. Lotsof is survived by his wife, Norma, and two sisters
Rosalie Falato and Holly Weiland.





